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Y. Feng, A. Martin* (2022) Mutagenic repair during antibody diversification: Emerging insights. Trends in Immunology. In Press.

M. Wong, J. Liu, P. Budylowksi, E. Yue, Z. Li, J. Rini, J. Carlyle, A. Zia, M. Ostrowski*, A. Martin* (2022) Convergent CDR3 homology amongst Spike-specific antibody responses in convalescent COVID-19 patients receiving the BNT162b2 vaccine. Clinical Immunol. Vol 237, p.1-11.

Wong, E. Brownlie, K. Ng, S. Kathirgamanathan, B. Yu, B. Merrill, K. Huang, A. Martin, C. Tropini, and W. Navarre (2022) The CIAMIB: a large and metabolically diverse collection of inflammation-associated bacteria from the murine gut. mBio.Vol 13, p.1-18.


Y. Feng, C. Li, J. Stewart, P. Barbulescu, N. Desivo, A. Álvarez-Quilón, R. Pezo, M. Perera, K. Chan, A. Tong, R. Mohamad-Ramshan, M. Berru, D. Nakib, G. Li, G. Kardar, J. Carlyle, J. Moffat, D. Durocher, J. Di Noia, A. Bhagwat, A. Martin* (2021) FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature. Vol. 600, p. 324-328.

T. Irrazabal, B. Thakur, K. Croitoru, A. Martin* (2021) Preventing Colitis-associated Colon Cancer with antioxidants: A systematic Review. Cell. Mol. Gastro. Hepat. Vol. 4, p. 1177-1197

C. Maisonneuve, D. Tsang, E. Foerster, T. Mukherjee, D. Prescott, I. Tattoli, P. Lemire, D. Winer, S. Winer, C. Streutker, K. Geddes, K. Cadwell, R. Ferrero, A. Martin, S. Girardin, D. Philpott (2021) Nod1 Promotes Colorectal Carcinogenesis by Regulating the Immunosuppressive Functions of Tumor-Infiltrating Myeloid Cells. Cell Reports. Vol. 34, p. 1-18


M. Galati, K. Hodel, M. Gams, S. Sudhaman, T. Bridge, W. Zahurancik, V. Park, A. Ercan, L. Joksimovic, I. Siddiqui, R. Siddaway, M. Edwards, R. de Borja, D. Elshaer, J. Chung, V. Forster, N. Nunes, M. Aronson, X. Wang, J. Ramdas, A. Seeley, T. Sarosiek, G. Dunn, J. Byrd, O. Mordechai, C. Durno, A. Martin, A. Shlien, E. Bouffet, Z. Suo, J. Jackson, C. Hawkins, C. Guidos, Z. Pursell, & U. Tabori (2020) Cancers from Pole mutant mice provide insights into polymerase-mediated hypermutagenesis and immune checkpoint blockade. Cancer Research. Vol 80, p. 5606-5618

Olivieri, T. Cho, A. Álvarez-Quilón, K. Li, M. Schellenberg, M. Zimmermann, N. Hustedt, S. Rossi, S. Adam, H. Melo, A. Margriet Heijink, G. Sastre-Moreno, N. Moatti, R. Szilard, A. McEwan, A. Ling, A. Serrano Benitez, T. Ubhi, G. Brown, F. Cortes-Ledesma., R. Scott Williams, A. Martin, D. Xu and D. Durocher (2020) A genetic map of the response to DNA damage in human cells. Cell. Vol. 182, p. 481-496

A. Ling, M. Munro, N. Chaudhary, C. Li, M. Berru, B. Wu, D. Durocher, A. Martin* (2020) SHLD2 promotes class switch recombination in B cells by preventing large inactivating deletions within immunoglobulin heavy chain loci. EMBO Reports. Vol 21, p. 1-13

Y. Feng, N. Seija, J. Di Noia*, A. Martin* (2020) AID in Antibody Diversification: There and Back again. Trends in Immunology. Vol 41, p. 586-600

T. Irrazabal, B. Thakur, M. Kang, Y. Malaise, C. Streukter, E. Wong, J. Copeland, D. Guttman, W. Navarre, A. Martin* (2020) Limiting Oxidative DNA Damage Reduces Microbial-induced Colitis Associated Colorectal Cancer. Nature Communications. Vol 11, 1802, p.1-14

C. Li, E. Lam, C. Perez-Shibayama, L. Ward, J. Zhang, D. Lee, A. Nguyen, M. Ahmed, E. Brownlie, K. Korneev, O. Rojas, T. Sun, W. Navarre, H. He, A. Martin, B. Ludewig, and J. Gommerman (2020) Early life programming of Mesenteric Lymph Node Stromal Cell Identity by the Lymphotoxin Pathway Regulates Adult Immune Responses. Science Immunology. Vol. 4 p. 1-17


R. Pezo*, M. Wong, and A. Martin* (2019) Gut microbes and immune checkpoint inhibitor-associated toxicities. Therapeutic Advances in Gastroenterology. Vol. 12, p. 1-10

C. So and A. Martin* (2019) DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells. PLoS Genetics. Vol. 15, e1008101

C. So, S. Ramachandran, A. Martin* (2019) E3 ubiquitin ligases RNF20 and RNF40 are required for DSB repair: evidence for monoubiquitination of histone H2B lysine 120 as a novel axis of DSB signaling and repair. Mol Cell Biol. Vol. 39, e00488-18

B. Thakur, Y. Malaise, A. Martin*. (2019) Unveiling the Mutational Mechanism of the Bacterial Genotoxin Colibactin in Colorectal Cancer. Molecular Cell. Vol 74, p. 227-229

R. Nepal & A. Martin* (2019) Pillars in Immunology: Unmasking the Mysteries of Myc. J. Immunology. Vol 202, p. 2517-2518


C. Li, T. Irrazabal, C. So, M. Berru, L. Du, E. Lam, J. Gommerman, Q. Pan-Hammarström, & A. Martin* (2018) The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non homologous end joining. Nature Communications. Vol 9, 1006, p.1-12

A. Ling, C. So, M. Le, A. Chen, L. Hung, A. Martin* (2018) Double stranded DNA break polarity skews repair pathway choice during intra- and inter-chromosomal recombination. PNAS USA. Vol 115, p2800-2805

S. Nordermeer, S. Adam, D. Setiaputra, M. Barazas, S. Pettitt, A. Ling, M. Olivieri, A. Alvarez Quilon, N. Moatti, M. Zimmermann, S. Annunziato, D. Krastev, A. Sherker, S. Landry, R. Szilard, M. Munro, A. McEwan, T. Goullet de Rugy, Z. Lin, T. Hart, J. Moffat, A. Gingras, A. Martin, H. van Attikum, J. Jonkers, C. Lord, S. Rottenberg, D. Durocher (2018) The Shieldin complex mediates 53BP1-dependent DNA repair. Nature. Vol 560, p117-121

M. Tanaka, J. Fine, C. Kirkham, O. Aguilar, A. Belcheva, A. Martin, T. Ketela, J. Moffat, D. Allan, J. Carlyle (2018) The inhibitory NKR-P1B:Clr-b recognition axis facilitates detection of oncogenic transformation and cancer immunosurveillance. Cancer Research. Vol 78, p3589-3603

G. Galicia, D. Lee, V. Ramaglia, L. Ward, J. Yam, Y. Leung, R. Li, M. Handy, J. Zhang, P. Drohomyrecky, S. Dunn, E. Lancaster, A. Bar-Or, A. Martin, J. Gommerman. (2018) Isotype-switched auto-antibodies are necessary to facilitate CNS autoimmune disease in Aicda-/- and Ung-/- mice. J. Immunology. Vol. 20, p1119-1130

B. Green, A. Martin, A. Belcheva (2018) Deficiency in the DNA glycosylases UNG1 and OGG1 does not potentiate c-Myc-induced B cell lymphomagenesis. Experimental Hematology, Vol 61, p52-58.

C. Maisonneuve, T. Irrazabal, A. Martin, S. Girardin, & D. Philpott (2018) The impact of the gut microbiome on colorectal cancer. Annual Review Cancer Biology. Vol 2, p. 229-249.

T. Irrazabal, A. Martin* (2018) Microbiota and Colon Cancer: Orchestrating neoplasia through DNA damage and immune dysregulation. Encyclopedia of Cancer, 3rd edition. Elsevier, In press.


M. Kang & A. Martin* (2017) Microbiome and colorectal cancer: Unraveling host-microbiota interactions in colitis-associated colorectal cancer development. Seminars in Immunology. Vol 32, p. 3-13.

S. Oke, A. Martin* (2017) Insights into the role of the intestinal microbiota in colon cancer. Therapeutic Advances in Gastroenterology. Vol 10, p. 417-428

K. Bromberg, T. Mitchell, A. Upadhyay, C. Jakob, L. Lasko, C. Li, C. Tuzon, Y. Dai, F. Li, M. Eram, A. Nuber, N. Soni, V. Manaves, M. Algire, R. Sweis, M. Torrent, G. Schotta, C. Sun, M. Michaelides, A. Shoemaker, C. Arrowsmith, P. Brown, V. Santhakumar, A. Martin, J. Rice, G. Chiang, M. Vedadi, D. Barsyte-Lovejoy and W. Pappano (2017) The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in the maintenance of genomic integrity. Nature Chemical Biology. Vol 13, p317-324


M. Le , D. Haddad , A. Ling, C. Li, C. So, A. Chopra, R. Hu, J. Angulo, J. Moffat, A. Martin* (2016) Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching. Scientific Reports 6:37215

S. Ramachandran, D. Haddad, C. Li, M. Le, A. Ling, C. So, R. Nepal, J. Gommerman, K. Yu, T. Ketela, J. Moffat, A. Martin* (2016) The SAGA deubiquitination module promotes DNA repair and class switch recombination through DNAPK-mediated gH2AX formation. Cell Reports. Vol. 15, p1554–1565

S. Li & A. Martin* (2016) Mismatch Repair and Colon Cancer: Mechanisms and Therapies Explored. Trends in Molecular Medicine. Vol 22, p. 274-289


Irrazábal* & A. Martin* (2015) T regulatory cells gone bad: An oncogenic immune response against enterotoxigenic B. fragilis infection leads to colon cancer. Cancer Discovery. Vol. 5, p. 1021-1023

A. Belcheva*, T. Irrazábal, A. Martin* (2015) Gut microbial metabolism and colon cancer: Can manipulations of the microbiota be useful in the management of gastrointestinal health. BioEssays. Vol. 37, p. 403-12

A. Belcheva & A. Martin* (2015) Gut microbiota and colon cancer: the carbohydrate link. Molecular Cellular Oncology. Vol 2. p. 1-2


S. Shalhout, D. Haddad, A. Sosin, AT. Holland, A. Al-Katib, A. Martin, A. Bhagwat (2014) Homeostasis in Genomic Uracil Creation and Elimination during Normal B Cell maturation, and loss of this balance during B Cell cancer development. Mol Cell Biol. Vol. 34, p. 4019-32.

K. Johnson-Henry, L. Pinnell, A. Waskow, T. Irrazabal, A. Martin, M. Hausner, P.M. Sherman(2014) Effects of a Short-Chain Fructo-oligosaccharide and Inulin in Caco2-bbe and C57Bl/6 Mice Models of Intestinal Injury. J. Nutrition. Vol. 144, p. 1725-33

F. Soares, I. Tattoli, M. Rahman, S. Robertson, A. Belcheva, D. Liu, C. Streutker, S. Winer, D. Winer, D. Arnoult, A. Martin, D. Philpott, S. Girardin (2014) The mitochondrial protein NLRX1 controls apoptotic cell death in cancer cells. J. Biol Chem. Vol. 289, p.19317-30.

A. Belcheva, T. Irrazabal, S. Robertson, C. Streutker, E. Moriyama, H. Maughan, S. Kumar, B. Green, S. Rubino, R. Pezo, W. Navarre, M. Milosevic, B. Wilson,  S. Girardin, W. Edelmann, T. Wolever, D. Guttman, D. Philpott, A. Martin*(2014) Gut microbial metabolism fuels colorectal cancer in Msh2-deficient hosts. Cell. Vol. 158, p. 288-299.

T. Irrazábal, A. Belcheva, S. Girardin, A. Martin* and D. Philpott*(2014) The multifaceted role of the intestinal microbiota in colon cancer. Molecular Cell. Vol. 54, p. 309-20.


B. Boulianne, O. Rojas, D. Haddad, A. Zaheen, A. Kapelnikov, T. Nguyen, J. Gommerman*, A. Martin*  (2013) AID and Caspase 8 shape the germinal center response through apoptosis. J. Immunology. Vol. 191, p. 5840-47.

 B. Boulianne, M. Le, L. Ward, L. Meng, A. Martin*, J. Gommerman* (2013)Lymph Node Germinal Centers form in the absence of Follicular Dendritic Cells, but their maintenance and function requires Lymphotoxin-b Receptor signaling. J. Immunology.   Vol. 191, p. 4521-30.

A. Belcheva, B. Green, A. Weiss, C. Streutker, A. Martin* (2013). Elevated incidence of polyp formation in APCMin/+Msh2-/- mice is independent of nitric oxide-induced DNA mutations. PLoS One. Vol. 8(5), e65204.

G. Galicia-Rosas, B. Boulianne, N. Pikor, A. Martin, J. Gommerman (2013) Secondary B cell Receptor diversification is necessary for T cell mediated neuroinflammation during Experimental Autoimmune Encephalomyelitis. PLoS One. Vol. 8(4), e61478.


M. Larijani* & A. Martin* (2012) The Biochemistry of Activation-Induced Cytidine Deaminase and its physiological functions. Seminars Immunology. Vol. 40, p. 548-563.

H. Li, R.M. Nepal, A. Martin, S.A. Berger (2012). Induction of apoptosis in Eμ-myc lymphoma cells in vitro and in vivo through calpain inhibition. Expt. Hematology. Vol. 40, p. 548-563.

J. Parsa, S. Ramachandran, A. Zaheen, R. Nepal, A. Kapelnikov, A. Belcheva, M. Berru, D. Ronai, A. Martin* (2012). Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis. PLoS Genetics. Vol. 8, e1002518.

A. Dancyger, J. King, M. Quinlan, H. Fifield, S. Tucker, H. Saunders, M. Berru, B. Magor, A. Martin, M. Larijani (2012). Differences in the enzymatic efficiency of bony fish and human AID are mediated by a single residue in the C-terminus that modulates single-stranded DNA binding. FASEB J. Vol. 26, p.1517-25.

J.H. Fritz, D. McCarthy, N. Simard, O. Lucia Rojas, S. Hapfelmeier, S. Rubino, S. Robertson, M. Larijani, I. Ivanov, A. Martin, R. Casellas, D. Philpott, S. Girardin, K. McCoy, A. Macpherson, C. Paige and J. Gommerman (2012).Acquisition of a multifunctional TNF/iNOS-producing IgA+ plasma cell phenotype in the gut. Nature. Vol. 481, p.199-203.


B. Green, A, Belcheva, R.M. Nepal, B. Boulianne, and A. Martin (2011)The mismatch repair pathway functions normally at a non-AID target in germinal center B cells. Blood. Vol. 118, p. 3013-8.

B. Duvvuri, V. Duvvuri, J. Grigull, A. Martin, Q. PanHammarstrom, G.E. Wu, M. Larijani (2011). Altered spectrum of somatic hypermutation in Common Variable Immunodeficiency Disease characteristic of defective repair of AID-induced mutations. Immunogenetics. Vol. 63, p.1-11.

A. Zaheen and A. Martin (2011) Activation induced cytidine deaminase and aberrant germinal center selection in the development of humoral autoimmunities. Amer. J. of Pathology. Vol. 178, p.462-71.


S. Ramachandran, R. Chahwan, R.M. Nepal, D. Frieder, S. Panier, A. Zaheen, D. Durocher, M. Scharff, and A. Martin (2010). The RNF8/RNF168 ubiquitin ligase cascade is required for class switch recombination. Proc Natl Acad Sci USA.Vol. 107, p. 809-814


R.M. Nepal, L. Tong, B. Kolaj, W. Edelmann, A. Martin (2009). Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-myc-induced lymphomas. Proc Natl Acad Sci USA. Vol. 106, p. 18698-703.

D. Frieder, M. Larijani, C. Collins, M. Shulman, A. Martin (2009). The concerted action of Msh2 and UNG stimulates error-prone repair at A:T basepairs in hypermutating B cells. Mol Cell Biol. Vol. 18, p. 5148-57.

A. Zaheen, B. Boulianne, S. Ramachandran, J.Y. Parsa, J.L. Gommerman, A. Martin (2009). AID constrains Germinal Center size by Rendering B cells Susceptible to Apoptosis. Blood. Vol. 114, p.547-554.


R.M. Nepal, A. Zaheen, W. Basit, L. Li, S.A. Berger, A. Martin (2008). AID and RAG1 do not contribute to lymphomagenesis in Em c-myc transgenic mice. Oncogene. Vol. 27, p.4752-6.


S.A. Lee, J.Y. Parsa, A. Martin, M.D. Baker(2007). Preferential integration of plasmid DNA into the immunoglobulin switch m region in hybridoma cells expressing activation-induced cytidine deaminase. Eur J Immunol. Vol. 37, p. 3529-39

M. Larijani, A. Martin (2007). ssDNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID. Mol Cell Biol. Vol. 27, p. 8038-48.

D. Ronai, M.D. Iglesias-Ussel, M. Fan, Z. Li, A. Martin, M.D. Scharff(2007) Detection of Chromatin-Associated ssDNA in Regions Targeted for Somatic Hypermutation. J. Exp. Med. Vol. 204, p.181-190.

E.S. Tang, A. Martin. (2007) Immunoglobulin Gene Conversion: Synthesizing antibody diversification and DNA repair. DNA Repair. Vol. 6, p. 1557-71.

M. Larijani, A. Petrov, O. Kolenchenko, M. Berru, S. Krylov and A. Martin (2007). AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner. Mol Cell Biol. Vol. 27, p.20-30.

J.Y. Parsa, W. Basit, C.L. Wang, J.L. Gommerman, J.R. Carlyle, A. Martin (2007)AID mutates a non-immunoglobulin transgene independent of chromosomal position. Mol Immunol. Vol. 44 p. 567-75.


E.S. Tang, A. Martin. (2006) NHEJ-deficient DT40 cells have increased levels of immunoglobulin gene conversion: Evidence for a double strand break intermediate. Nucleic Acids Research. Vol. 34, p.6345-51.

D. Frieder, M. Larijani, E. Tang, J. Parsa, W. Basit, A. Martin (2006) Antibody diversification: mutational mechanisms and oncogenesis. Immunologic Research. Vol. 35, p.75-88.


M. Larijani, A. Zaheen, D. Frieder, Y. Wang, G.E. Wu, W. Edelmann, A. Martin (2005) Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events.Nucleic Acids Research. Vol. 33, p. 6733-6742.

M. Larijani, D. Frieder,W. Basit, A. Martin (2005) The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung-/-msh2-/- mice. Immunogenetics. Vol. 56, p.840-5.

M. Larijani, D. Frieder, T. Sonbuchner, R. Bransteitter, M. Goodman, E. Bouhassira, M. Scharff, A. Martin (2005) Methylation protects cytidines from AID-mediated deamination. Mol Immunol. Vol. 42, p.599-604.


Z. Li, S. Scherer, D. Ronai, M. Iglesias, J. Peled, P. Bardwell, M. Zhuang, K. Lee, A. Martin , W. Edelmann, M. Scharff (2004). Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinctive roles of MutS homologues in antibody diversification. J. Exp. Med. Vol. 200, p.47-59.


P. Bardwell, C. Woo, K. Wei, Z. Li, A. Martin , S. Sack, W. Edelmann, M Scharff (2003). Altered somatic hypermutation and reduced class switch recombination in Exonuclease 1-mutant mice.  Nat. Immunology. Vol. 5, p. 224-229.

A. Martin , Z. Li, D Lin, P. Bardwell, M. Iglesias, W. Edelmann, M. Scharff (2003). ATPase activity of Msh2 is essential for somatic hypermutation at A-T basepairs and for efficient class switch recombination. J. Exp. Med. Vol. 200, p.47-59.

C. Woo, A. Martin , M. Scharff (2003). Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin. Immunity. Vol. 19, p. 479-489.

P. Bardwell, A. Martin , E. Wong, Z. Li, W. Edelmann, M. Scharff (2003). The G-U mismatch glycosylase Mbd4 is dispensable for somatic hypermutation and class switch recombination. J. Immunol. Cutting Edge. Vol. 170, p. 1620.


A. Martin and M. Scharff (2002) Somatic hypermutation of the AID transgene in B and non-B cells.Proc Natl Acad SciUSA . Vol. 99, p. 12304.

P. Bardwell, A. Martin , M. Scharff (2002) Mutation detection of immunoglobulin V-regions by DHPLC. J. Immunol. Meth., Vol. 266, p. 165.

A. Martin and M. Scharff (2002) AID and mismatch repair in antibody diversification. Nat. Rev. Immunol., Vol. 2, p. 605.

A. Martin , P. Bardwell, C. Woo, M. Fan, M. Shulman, M. Scharff (2002) Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature, Vol. 415, p. 802-806.


A. Martin and M. Scharff (2001) Antibody Alterations (News and Views). Nature, Vol. 412, p. 870-871.

W. Zhang, P. Bardwell. C. Woo, V. Poltoratsky, M. Scharff, A. Martin (2001). Clonal instability of V-region hypermutation in the Ramos Burkitt’s lymphoma cell line. Internat. Immunol., Vol. 13, p. 1175-1184.

V. Poltoratsky, C Woo, B. Tippin, A. Martin , M Goodman, M Scharff (2001) Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation. Proc Natl Acad Sci USA, Vol. 98, p.7976-7981.

* Corresponding author